![]() Moving on to address cancer treatment, it then follows that containing cancer cell growth and re-instituting cell growth regulation can be a possible means of managing development or curing a patient. As cells replicate unregulated, masses grow, becoming cancerous nodes or masses. In a cancerous state, regulation is impaired and rapid mitosis, or quickly developing cell division and multiplication, takes place. Returning to a normal state of homeostasis, or the G1 phase, is the typical course of a healthy cell. Some natural checkpoints exist that serve to maintain regulation of what the cell needs to be doing and where in its life cycle it should be. It then discusses how the normal cycles of cell life and mitosis can be affected and altered, leading to cancer cell growth. The project’s explanation dives into more details of cell division, giving the process context within the larger, overarching cell cycle. Clay models highlight the strands of tightly wound DNA that gather into chromosomes and split along the center of the dividing cell. Each step is shown in sequential order with arrows showing progression from interphase to prophase, to prometaphase, to metaphase, to telophase, to cytokinesis. This project uses multiple types of visual art to display the steps of mitosis within the cell cycle and how genetic material is split between the daughter cells. Regulation of kinetochore configuration during mitosis. Topham, Taylor, Mitosis and apoptosis: how is the balance set?, Current Opinion in Cell Biology, Volume 25, Issue 6, 2013,Pages 780-785,ISSN 0955-0674,ĭhatchinamoorthy, K., Mattingly, M. Dhatchinamoorthy’s research states that the kinetochores in the cell cycle is actually plastic ( Dhatchinamoorthy, 2018). The change from aerobic processes to anaerobic processes in a cancer cell can increase the cancer cell’s likelihood to survive and undergo mitosis. In Topham’s research states that anti-mitotic agents are used in chemotherapy patients to stop the uncontrolled replication of the cancer cells. However, cancer cells do not abide by cell regulation and will continue to grow and replicate. When a cell is not ready for the next phase in the cell cycle, it undergoes apoptosis or returns to the G 1 phase. The cell cycle is regulated, and when it becomes uncontrolled (unregulated) it’s considered cancer. These checkpoints ensure that each cell is ready for the next step, and they also ensure that there was no genetic mutations. There are multiple checkpoints within the cell cycle that helps regulate cell production. Interphase is essentially when the cell is not actively dividing, so all phases of the cell cycle except for the mitotic phase and cytokinesis. The cell cycle consists of the gap 1 phase (G 1 phase), synthesis phase (S phase), and gap 2 phase (G 2 phase), and lastly, the mitotic phase. Mitosis plays a major role in the cell cycle and its regulation. Mitosis, also known as the mitotic phase within the cell cycle, consists of seven phases: prophase, prometaphase, metaphase, anaphase, telophase, and lastly cytokinesis.
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